Genetically modified mouse models to investigate thyroid development, function and growth
The thyroid gland produces thyroid hormones (TH), which are essential regulators for
growth, development and metabolism. The thyroid is mainly controlled by the thyroid-
stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its
action via different G protein-mediated signaling pathways. TSH primarily activates the G s-
pathway, and at higher concentrations also the G q/11-pathway, leading to an increase of
intracellular cAMP and Ca 2+, respectively. To date, the physiological importance of other G …
growth, development and metabolism. The thyroid is mainly controlled by the thyroid-
stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its
action via different G protein-mediated signaling pathways. TSH primarily activates the G s-
pathway, and at higher concentrations also the G q/11-pathway, leading to an increase of
intracellular cAMP and Ca 2+, respectively. To date, the physiological importance of other G …
