Protein misfolding in the endoplasmic reticulum as a conduit to human disease
M Wang, RJ Kaufman - Nature, 2016 - nature.com
Nature, 2016•nature.com
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein
synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or
unfolded proteins—known as endoplasmic reticulum stress—and the activation of the
adaptive unfolded protein response to restore homeostasis. If protein misfolding is not
resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein …
proteins that enter the secretory pathway. Environmental insults or increased protein
synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or
unfolded proteins—known as endoplasmic reticulum stress—and the activation of the
adaptive unfolded protein response to restore homeostasis. If protein misfolding is not
resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein …
Abstract
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of proteins that enter the secretory pathway. Environmental insults or increased protein synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or unfolded proteins — known as endoplasmic reticulum stress — and the activation of the adaptive unfolded protein response to restore homeostasis. If protein misfolding is not resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein response help to determine cell fate and function. Furthermore, endoplasmic reticulum stress contributes to the aetiology of many human diseases.
nature.com
