Dysplasia and dysregulation of proliferation in foveolar and surface epithelia of fundic gland polyps from patients with familial adenomatous polyposis
TT Wu, S Kornacki, A Rashid, JH Yardley… - The American journal …, 1998 - journals.lww.com
Fundic gland polyps (FGPs) of the stomach are regarded as hamartomatous or
hyperplastic/functional polyps that occur sporadically but at increased frequency in patients
with familial adenomatous polyposis syndrome (FAP). There is controversy about the
histopathology of FGPs, including occurrence of dysplasia. We, therefore, studied dysplasia
in 270 sporadic FGPs from 216 patients and 49 FGPs from 24 patients with FAP. We
evaluated dysregulation of epithelial proliferation manifested by loss of the normal inverse …
hyperplastic/functional polyps that occur sporadically but at increased frequency in patients
with familial adenomatous polyposis syndrome (FAP). There is controversy about the
histopathology of FGPs, including occurrence of dysplasia. We, therefore, studied dysplasia
in 270 sporadic FGPs from 216 patients and 49 FGPs from 24 patients with FAP. We
evaluated dysregulation of epithelial proliferation manifested by loss of the normal inverse …
