[HTML][HTML] HOPX: the unusual homeodomain-containing protein
A Mariotto, O Pavlova, HS Park, M Huber… - Journal of Investigative …, 2016 - Elsevier
A Mariotto, O Pavlova, HS Park, M Huber, D Hohl
Journal of Investigative Dermatology, 2016•ElsevierThe homeodomain-only protein homeobox (HOPX) is the smallest known member of the
homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely
expressed in diverse tissues, where it is critically involved in the regulation of proliferation
and differentiation. In human skin, HOPX controls epidermal formation through the
regulation of late differentiation markers, and HOPX expression correlates with the level of
differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a …
homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely
expressed in diverse tissues, where it is critically involved in the regulation of proliferation
and differentiation. In human skin, HOPX controls epidermal formation through the
regulation of late differentiation markers, and HOPX expression correlates with the level of
differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a …
The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation. In human skin, HOPX controls epidermal formation through the regulation of late differentiation markers, and HOPX expression correlates with the level of differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a lineage tracing marker of quiescent hair follicle stem cells. This review discusses current knowledge of HOPX structure and function in normal and pathological conditions.
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